top of page

Brent Page Lab
UBC Pharmaceutical Sciences

At the interface of chemical biology and drug discovery

Recent Publications

P. Iliev*, D. Hanke*, B.D.G. Page: STAT Protein Thermal Shift Assays to Monitor Protein‐Inhibitor Interactions, ChemBioChem 2022, e202200039

L.N Heppler, S. Attarha, R. Persaud, J.I. Brown, P. Wang, B. Petrova, I. Tošić, F.B. Burton, Y. Flamand, S.R. Walker, J.E. Yeh, R.A. Zubarev, M. Gaetani, N. Kanarek, B.D.G. Page, D. A. Frank: The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase.  J. Biol. Chem. 2022, 298 (2).

SM Zhang, D Rehling, AS Jemth, A Throup, N Landázuri, I Almlöf, M. Göttmann, N.C.K. Valerie, S.R. Borhade, P. Wakchaure, B.D.G. Page, M. Desroses, E.J. Homan, M. Scobie, S.G. Rudd, U. Warpman Berglund, C. Söderberg-Nauclér, P. Stenmark, T. Helleday: NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir, Cell Chem. Biol. 2021, 28 (12), 1693-1702.

M Pons, Y Zeyn, S Zahn, N Mahendrarajah, BDG Page, PT Gunning, R. Moriggl, W. Brenner, F. Butter, O.H. Krämer: Oncogenic kinase cascades induce molecular mechanisms that protect leukemic cell models from lethal effects of de novo dNTP synthesis inhibition, Cancers 2021, 13 (14), 3464.

P. P. Adhikary, Z. Tan, B.D.G. Page, S. Hedtrich: P. P. TSLP as Druggable Target – A Silver-Lining for Atopic Diseases? Pharmacol. Ther. 2021, 107648.

S. Busker, B. D. G. Page, E. Arner: To inhibit TrxR1 is to inactivate STAT3 – Inhibition of TrxR1 enzymatic function by STAT3 small molecule inhibitors, Redox Biol. 2020, 36, 101646. 

S.M Zhang*, M. Desroses*, A. Hagenkort*, N.C.K. Valerie, M. Carter, D. Rehling, O. Wallner, T. Koolmeister, A. Throup, I. Almlöf, O. Loseva, T. Lundbäck, H. Axelsson, S. Regmi, A. Sarno, L. Pudelko, L. Bräutigam, A.S. Jemth, M. Göttmann, E. Wiita, C. Kalderén, A. Cázares-Körner,  B..D.G. Page, R. Krimpenfort, E. Homan, M. Scobie, P. Stenmark, U. Warpman Berglund, T. Helleday:  Development of a chemical probe against NUDT15. Nat. Chem. Biol. 2020, 16, 1120-1128.

S. Attarha, A. Reithmeier, S. Busker, M. Desroses, B.D.G. Page†: Validating STAT Protein-inhibitor Interactions using Biochemical and Cellular Thermal Shift Assays. ACS Chem. Biol. 2020, 15 (7),1842-1851.

J. Brown, B.D.G. Page†, A. Frankel†: The application of differential scanning fluorimetry in exploring bisubstrate binding to protein arginine N-methyltransferase 1. Methods 2020, 175, 10-23. 

A.D. Smith, B.D.G. Page, A.C. Collier, M.W.H. Coughtrie: Homology Modeling of Human Uridine-5′-diphosphate-glucuronosyltransferase 1A6 Reveals Insights into Factors Influencing Substrate and Co-substrate Binding. ACS Omega 2020, 5, 12, 6872-6887. 

S. Busker, W. Qian, M. Haraldsson, B. Espinosa, L. Johansson, S. Attarha, I. Kolosenko5, J. Liu, M. Dagnell, D. Grandér, E.S.J. Arnér, K. Pokrovskaja-Tamm, B.D.G. Page†: Sci. Adv. 2020, 6, 12. 

M. Desroses, S. Busker, J. Astorga-Wells, S. Attarha, I. Kolosenko, R. A. Zubarev, T. Helleday, D. Grander, B. D. G. Page†: STAT3 differential scanning fluorimetry and differential scanning light scattering Assays: addressing a missing link in the characterization of STAT3 Inhibitor interactions, J. Pharm. Biomed. Anal. 2018, 160, 80-88. 


B. D. G. Page*†, N. C. K. Valerie*, R. H. G. Wright, O. Wallner, R. Isaksson, M. Carter, S. G. Rudd, O. Loseva, A. S. Jemth, I. Almlöf, J. Font-Mateu, S. Llona-Minguez, P. Baranczewski, F. Jeppsson, E. Homan, H. Almqvist, H. Axelsson, S. Regmi, A. L. Gustavsson, T. Lundbäck, M. Scobie, K. Strömberg, P. Stenmark, M. Beato, Thomas Helleday†: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nat. Commun. 2018, 9, 250. 


I. Kolosenko, Y. Yu, S. Busker, M. Dyczynski, J. Liu, M. Haraldsson, C. P. Apergi, T. Helleday, K. P. Tamm, B. D. G. Page, D. Grander: Identification of novel small molecules that inhibit STAT3-dependent transcription and function, Plos One, 2017, 12 (6), e0178844. 

See the full list via Google Scholar

bottom of page